Join us for the Autoimmune Community Summit, October 21 & 22. It’s designed for patients, care partners, and advocates — it’s FREE and virtual!

Search Autoimmune Association
Share this article
Am Omega Omega Benefits For Autoimmune Symptoms

Omega 3 & Omega 6 Benefits for Autoimmune Symptoms

Omega-3 and omega-6 are different types of essential fatty acids.  They are referred to as “essential” because your body cannot make them on its own, and thus must obtain them from dietary sources.  All fatty acids display a variety of beneficial properties, although too much of certain types can lead to biochemical imbalance and consequent disease.  The modern American diet tends to be too rich in omega-6 fatty acids, which promotes inflammation in your body and exacerbates many autoimmune conditions.

How might essential fatty acids help my autoimmune condition?

Of all the fatty acids,  the omega-3 polyunsaturated fatty acids (PUFA) have the greatest effect on the immune system and the inflammatory response.  This is potentially important for autoimmune diseases patients.  Studies examining the use of omega-3 supplements (usually taken as fish oil) have demonstrated benefits for people with chronic diseases, including autoimmune conditions such as lupus, ulcerative colitis, rheumatoid arthritis, psoriasis, multiple sclerosis and Crohn’s disease. These benefits include reduced pain and inflammation, with a consequent decreased need for medications designed to combat inflammation, which can have their own negative side effects.

What are some potential disadvantages of taking essential fatty acids?

The pathology of many autoimmune conditions involves an over-production of substances that trigger inflammation.  The inflammatory culprit is often something called arachidonic acid (AA), which is a type of PUFA derived from linoleic acid, an omega-6 fat common in Western diets.  Autoimmune Association can either block or promote inflammation (depending on the specific condition and the precise cause of the inflammation) in the cardiovascular, neurological, and gastrointestinal systems, among others.  Western diets, often too rich in omega-6 fats, without the counterbalance of protective omega-3 fats, may leave you at risk for heart disease, cancer, hypertension and diabetes. Similarly, the dietary lack of omega-3s (the primary ingredient in most fish oil blends) may render you less able to prevent or temper the inflammation of arthritis and some autoimmune disorders, because of the reduced natural anti-inflammatory mechanisms.  However, supplementation is not without its own risks either.  High doses of supplements can also have unwanted and potentially dangerous effects, such as an increased bleeding risk according to Mayo Clinic.  In addition, though not necessarily causative by themselves, such high doses for extended periods of time have been putatively linked to both prostate and breast cancers.

What is the best or most effective ratio of omega-6 to omega-3 fatty acids?

First, it’s important to understand that this may depend on the condition and its severity at a given time.  This is why it’s a good idea to speak to your doctor and perhaps a nutritionist prior to beginning a regimen of supplements aimed at limiting your disease state.  Recommended ratios may differ somewhat based on the disorder.

Before trans fats and processed foods were added to our diets, the ratio of omega-6 to omega-3 fatty acids was about 4:1, with a 70% lowered risk of death from heart disease. Research now indicates that the typical American diet contains anywhere from 10 to 30 times more omega-6 than omega-3 fats, owing in part to widespread use of vegetable oils (such as corn and safflower oils), margarine, salad dressing and heavily processed foods.  As a general rule, ratios of 10:1 or higher (omega-6:omega-3) are associated with adverse outcomes like higher rates of chronic inflammatory diseases, including autoimmune conditions. Some experts suggest ratios of no more than 2:1 for optimal health.  Thus, unless directed otherwise, you shouldn’t intentionally supplement with omega-6 fatty acids; instead you should take omega-3 supplements, while also reducing your dietary consumption of omega-6 fats.

What forms of omega-3 are most recommended?

There are multiple types of omega-3 fatty acids, although those from fish oil (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ), are the most biologically active.  While still beneficial, eating small amounts of fish each day doesn’t give your body enough EPA and DHA to make much of an impact on inflammatory conditions, so supplementing is often recommended.  Daily doses of EPA and DHA in the range of 3 to 6 grams have proven effective in this regard, although it can take up to three months before one sees such improvements.  While liquid fish oil may be more easily  digested and absorbed than capsules, such preparations often have a fishy aftertaste.  As a result, capsules or gel caps are the more commonly used forms.  These too may also have a slight odor once broken apart in the stomach, usually in the form of “fish burps”.  However, there are now companies offering “odorless” alternatives too, though they’re more expensive.

Questions for your doctor:

  • What cooking oils are low in omega-6 fatty acids?
  • What types of fish are highest in EPA and DHA?
  • How much EPA and DHA are in the typical fish oil capsule?




About the Author
Dr. Rothbard is a professional medical writer and consultant based in New York City, specializing in medical education articles targeted at a variety of audiences, from children through clinicians.  After leaving medicine, he worked as a biology and medical science educator for several years, before deciding to pursue writing full-time.  He may be reached at

This blog post was originally published by, written by Dr. Rothbard, and first published on Sep 15, 2012.

This post contains the opinions of the author. Autoimmune Association is not a medical practice and does not provide medical advice, diagnosis, or treatment. It is your responsibility to seek diagnosis, treatment, and advice from qualified providers based on your condition and particular circumstances. Autoimmune Association does not endorse nor recommend any products, practices, treatment methods, tests, physicians, service providers, procedures, clinical trials, opinions or information available on this website. Your use of the website is subject to our Privacy Policy.

Share this article

Join our email list

Receive the latest blog articles, news, and more right to your inbox!

Related articles you might be interested in

Am Addisons Disease Celiac Mom Story

Addison’s Disease & Celiac Mom Story: “The Autoimmune Snowball”

I was 32 years old.  I had just survived a miserable pregnancy and rough delivery, but instead of gaining my strength back and...
Am Addisons Disease

Addison’s Disease: Overview of Antibodies & Genetic Links

Addison’s disease, also known as primary adrenal insufficiency, is an endocrine condition involving destruction of parts of the adrenal gland (which sits atop...
Am Addisons Disease And Pregnancy

Addison’s Disease and Pregnancy

What are some implications for pregnancy with Addison’s disease? Among the many autoimmune diseases, Addison’s stands out as one with an often delayed...

Find more resources on autoimmunity

Learn more about autoimmunity, diagnosis tips, how to find a physician, and more.